![]() The urban aim of the project is to regenerate the second section of el Bosque de Chapultepec Image: Maureen M. ![]() Originally designed by Leónides Guadarrama and Alfonso Ramírez Ponce in 1964, the building took shape with an immense asymmetric hyperbolic paraboloid ceiling in concrete architecture. In the el Bosque de Chapultepec or the forest of Chapultepec in Mexico City, on the banks of Lago Mayor Chapultepec is an old modernist structure reflecting the iconic exploration and experimentation of modernism that emerged in Mexico in the 60s. While the concepts of conservation revolve around different parameters and principles across the country, depending on the geographical, historical and cultural adaptations, the core has always remained in keeping alive the old and reviving the past. Ruskin’s beliefs of restoration as an act similar to the attempt of raising the dead and Morris’ concerns remain a topic of discussion. From John Ruskin and William Morris’ anti-restoration movement to Eugène Viollet-le-Duc’s restoration works, the past has seen both sides of the movement. “We were able to better predict if a patient would respond to ICI therapy than the current clinical standard method as well as extract biological information that could help in further understanding the mechanisms behind ICI therapy response and resistance,” Patterson explained.Since the 19 th century, the concepts of architectural conservation and restoration have travelled through many directions of thought. This knowledge could be used to identify targets to enhance responses or mitigate resistance in patients with melanoma. ![]() The team found that leukocyte and T-cell proliferation regulation processes have some mutated genes that contribute to ICI treatment response and resistance. Patterson, first author on the paper, detailed that their research process involved training machine learning models on a dataset to predict whether a patient responds to ICI therapy, then confirming that the model was able to continually predict response or resistance to this treatment over multiple other datasets. ![]() Using publicly available de-identified clinical data, researchers investigated why some melanoma patients responded to ICI therapy and others did not. “We need better biomarkers to help select patients that are more likely to respond to ICI therapy and understand what factors can help to enhance responses and increase those numbers.” “This work aims to identify better and more biologically interpretable genomic predictors for immunotherapy responses,” notes Auslander. In particular, mutations in the processes of leukocyte and T-cell proliferation regulation show potential as biomarkers with reliable and stable prediction of ICI therapy response across multiple different datasets of melanoma patients. Noam Auslander, assistant professor in the Molecular & Cellular Oncogenesis Program of Wistar’s Ellen and Ronald Caplan Cancer Centre and Andrew Patterson, graduate student in the Auslander lab, have now identified novel predictors of ICI therapy for melanoma. Currently, the only FDA approved biomarker for ICI melanoma treatment is the tumour mutation burden assay, but the mechanisms linking it to ICI remain unclear. While this treatment has shown some clinical success in patients with advanced stages of melanoma, its efficacy depends on reliable predictors of a patient’s response to the therapy. ICI therapy, a type of treatment for melanoma (skin cancer) blocks proteins on tumour or immune cells that prevent the immune system from killing cancer cells. Using advanced computing technology scientists at the Wistar Institute (Philadelphia) have been able to provide evidence of novel, reliable biomarkers that better predict therapy response of patients undergoing immune checkpoint inhibitor (ICI) treatment.
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